3t3 cells — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7196	HG-10-102-01		LRRK2
	HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).		LRRK2
T21312	Afatinib	Afatinib free base,BIBW 2992	EGFR , Autophagy
	Afatinib (BIBW 2992) is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively).		EGFR , Autophagy
T1773	Afatinib Dimaleate	BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate	EGFR , HER , Autophagy
	Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act...		EGFR , HER , Autophagy
T11212	EPAC 5376753	5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione	cAMP
	EPAC 5376753 is an allosteric inhibitor of EPAC1 with an IC50 of 4 µM in Swiss 3T3 cells.		cAMP
T9650	AZ12672857		Src , Ephrin Receptor
	AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphorylation of EphB4 in transfected CHO-K1 cells with IC50 of 9 n...		Src , Ephrin Receptor
T3220	Euphorbiasteroid	Euphobiasteroid,Euphorbia factor L1	Others , AMPK
	Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.		Others , AMPK
T28740	SDZ-62-434	SDZ 62 434,SDZ62434	Platelet aggregation
	SDZ-62-434 is a platelet-activating factor inhibitor with antitumor activity that inhibits bombesin- and platelet-derived growth factor-induced DNA synthesis in quiescent Swiss 3T3 cells for the study of leukemia, human ...		Platelet aggregation
TN1206	2,4,6-Trihydroxybenzaldehyde		Others
	2,4,6-Trihydroxybenzaldehyde is a natural product		Others
T9491	Pyraclostrobin		Antibacterial , Antifungal
	Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.		Antibacterial , Antifungal
T60857	MKK7-COV-9		Others
	MKK7-COV-9 is a selective and potent covalent inhibitor of MKK7 with inhibitory effects on MKK7-induced protein-protein interactions.MKK7-COV-9 interrupts the activation of primary B-cells in response to LPS.MKK7-COV-9 s...		Others
T10849	CMLD012612		Others
	CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).		Others
T81291	Retrofractamide A
	Retrofractamide A, an amide constituent extracted from Piper chaba fruit, enhances adipogenesis in 3T3-L1 cells [1].
TN5090	Tachioside		Glucokinase
	Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows antiobesity activities. Tachioside can inhibit nitric oxid...		Glucokinase
T36821	FQI 1
	FQI 1 is an SV40 factor (LSF) inhibitor. FQI 1 inhibits cell proliferation, with IC50s of 3, 0.79, and 6.3 μM for NIH/3T3, HeLa, and A549 cells, respectively. FQI1 could be used in cancer research.
T10848	CMLD012073		Others
	CMLD012073 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits NIH/3T3 cells (IC50: 10 nM). CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4...		Others
T83127	AMPK activator 13		AMPK
	AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygen consumption rates. This compound is utilized in the study of...		AMPK
TN3112	5-Heneicosylresorcinol		NADPH-oxidase , Antifection
	5-Heneicosylresorcinol shows inhibitory effects on the release of β-hexosaminidase from RBL-2H3 cells, it also prevents triglyceride accumulation in 3T3-L1 cells. 5-Heneicosylresorcinol has nematicidal activity against n...		NADPH-oxidase , Antifection
TN5655	Broussonin B
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin B can induce neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, and show moderate inhibitory activities against a chymotrypsi...
T36330	Terrecyclic Acid
	Terrecyclic acid is a sesquiterpene originally isolated from A. terreus with antibiotic and anticancer activity. It is active against S. aureus, B. subtilis, and M. roseus (MICs = 25, 50, and 25 μg/ml, respectively). Ter...
T36542	Prostaglandin A2	Medullin
	PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some anti...